Koncocoo

Best Epidemiology

When Breath Becomes Air
#1 NEW YORK TIMES BESTSELLER • PULITZER PRIZE FINALIST • This inspiring, exquisitely observed memoir finds hope and beauty in the face of insurmountable odds as an idealistic young neurosurgeon attempts to answer the question What makes a life worth living? At the age of thirty-six, on the verge of completing a decade’s worth of training as a neurosurgeon, Paul Kalanithi was diagnosed with stage IV lung cancer. When Breath Becomes Air chronicles Kalanithi’s transformation from a naïve medical student “possessed,” as he wrote, “by the question of what, given that all organisms die, makes a virtuous and meaningful life” into a neurosurgeon at Stanford working in the brain, the most critical place for human identity, and finally into a patient and new father confronting his own mortality. I’ll go on.’” When Breath Becomes Air is an unforgettable, life-affirming reflection on the challenge of facing death and on the relationship between doctor and patient, from a brilliant writer who became both. And part comes from the way he conveys what happened to him—passionately working and striving, deferring gratification, waiting to live, learning to die—so well.” —Janet Maslin, The New York Times. The book brims with insightful reflections on mortality that are especially poignant coming from a trained physician familiar with what lies ahead.” — The Boston Globe. When Paul Kalanithi is given his diagnosis he is forced to see this disease, and the process of being sick, as a patient rather than a doctor--the result of his experience is not just a look at what living is and how it works from a scientific perspective, but the ins and outs of what makes life matter. As he wrote to a friend: ‘It’s just tragic enough and just imaginable enough.’ And just important enough to be unmissable.” —Janet Maslin, The New York Times “Paul Kalanithi’s memoir, When Breath Becomes Air, written as he faced a terminal cancer diagnosis, is inherently sad. It is, despite its grim undertone, accidentally inspiring.” — The Washington Post “Paul Kalanithi’s posthumous memoir, When Breath Becomes Air, possesses the gravity and wisdom of an ancient Greek tragedy. [Kalanithi] is so likeable, so relatable, and so humble, that you become immersed in his world and forget where it’s all heading.” — USA Today “It’s [Kalanithi’s] unsentimental approach that makes When Breath Becomes Air so original—and so devastating. Its only fault is that the book, like his life, ends much too early.” — Entertainment Weekly “[ When Breath Becomes Air ] split my head open with its beauty.” —Cheryl Strayed. “Rattling, heartbreaking, and ultimately beautiful, the too-young Dr. Kalanithi’s memoir is proof that the dying are the ones who have the most to teach us about life.” —Atul Gawande “Thanks to When Breath Becomes Air, those of us who never met Paul Kalanithi will both mourn his death and benefit from his life. Kalanithi strives to define his dual role as physician and patient, and he weighs in on such topics as what makes life meaningful and how one determines what is most important when little time is left. This deeply moving memoir reveals how much can be achieved through service and gratitude when a life is courageously and resiliently lived.” — Publishers Weekly “A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity . Every doctor should read this book—written by a member of our own tribe, it helps us understand and overcome the barriers we all erect between ourselves and our patients as soon as we are out of medical school.” —Henry Marsh, author of Do No Harm: Stories of Life, Death, and Brain Surgery “A tremendous book, crackling with life, animated by wonder and by the question of how we should live.
Reviews
"Ultimately there's not much triumph in it in the traditional sense but there is a dogged, quiet resilience and a frank earthiness that endures long after the last word appears. Dr. Kalanithi talks about his upbringing as the child of hardworking Indian immigrant parents and his tenacious and passionate espousal of medicine and literature. He speaks lovingly of his relationship with his remarkable wife - also a doctor - who he met in medical school and who played an outsized role in supporting him through everything he went through. He had a stunning and multifaceted career, studying biology and literature at Stanford, then history and philosophy of medicine at Cambridge, and finally neurosurgery at Yale. The mark of a man of letters is evident everywhere in the book, and quotes from Eliot, Beckett, Pope and Shakespeare make frequent appearances. Metaphors abound and the prose often soars: When describing how important it is to develop good surgical technique, he tells us that "Technical excellence was a moral requirement"; meanwhile, the overwhelming stress of late night shifts, hundred hour weeks and patients with acute trauma made him occasionally feel like he was "trapped in an endless jungle summer, wet with sweat, the rain of tears of the dying pouring down". The painful uncertainty which he documents - in particular the tyranny of statistics which makes it impossible to predict how a specific individual will react to cancer therapy - must sadly be familiar to anyone who has had experience with the disease. There are heartbreaking descriptions of how at one point the cancer seemed to have almost disappeared and how, after Dr. Kalanithi had again cautiously made plans for a hopeful future with his wife, it returned with a vengeance and he had to finally stop working."
"He says this, “The secret is to know that the deck is stacked, that you will lose, that your hands or judgment will slip, and yet still struggle to win …You can’t ever reach perfection, but you can believe in an asymptote toward which are ceaselessly striving. In the foreword by fellow doctor and writer Abraham Verghese, that doctor writes, “He (Paul) wasn’t writing about anything—he was writing about time and what it meant to him now, in the context of his illness.” And in the afterword by his wife Lucy, the meaning of that time becomes even clearer."
"The beautifully written epilogue, which was written by his wife Lucy, will break your heart, and give you hope at the same time. It never occurred to me that you could love someone the same way after he was gone, that I would continue to feel such love and gratitude alongside the terrible sorrow, the grief so heavy that at times I shiver and moan under the weight of it.""
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Survival and Event History Analysis (Statistics for Biology and Health)
The common denominator of such models is stochastic processes. Stochastic processes are also used as natural models for individual frailty; they allow sensible interpretations of a number of surprising artifacts seen in population data.The stochastic process framework is naturally connected to causality. It will expose them to ideas they are unlikely to encounter in depth in a standard curriculum and is precisely the sort of book to inspire theses and other research projects. Prerequisites include exposure to stochastic processes and basic survival analysis, as well as the mathematical statistics that the standard graduate program provides. Each chapter contains relevant probability theory and data analyses and concludes with a set of exercises.... With its comprehensive and up-to-date bibliography, and extensive index, it is also ideal for self-study.… The book has Springer’s high quality with pleasing typesetting and good margins." … Aalen, Borgan and Gjessing have written a new book which is also likely to have a profound influence on the subject, possibly both from the classical and Bayesian point of view … . … In conclusion, this is an excellent book which will be useful to researchers in several fields due to the broad interest of the presented methodologies … .” (Bruno Betrò, Mathematical Reviews, Issue 2010 b) “Inspired by the spread of survival and event history analysis to fields beyond biostatistics and by the increasing complexity of high-quality data structures, the authors have written an elegant text that bridges theory and applications and balances technical detail with pedagogical simplicity. …Overall, the book is masterfully written and a welcome addition to the bookshelf of anyone doing either applied modeling or methodological research in survival or event history analysis.” (Journal of the American Statistical Association, Vol. Examples are individuals that move among several states, frailty that makes some units fail before others, internal time-dependent covariates, and the estimation of causal effects from observational data. Beginning with standard analyses such as Kaplan-Meier plots and Cox regression, the presentation progresses to the additive hazard model and recurrent event data. The authors show how dynamic path analyses can incorporate many modern causality ideas in a framework that takes the time aspect seriously.
Reviews
"For example, of utmost importance in survival analysis is that of censored data, and it only takes the author 2 pages to begin discussing how to handle this kind of data, wherein they motivate the difference between survival analysis and ordinary statistical analysis when it comes to censoring data. The authors give many examples that illustrate the many complexities that the hazard rate can exhibit, and of crucial importance in some of these examples is the actual shape of the hazard rate. The authors show how to extend these models to take into account unobservable heterogeneities between individuals by using frailty models, wherein the hazard rate of an individual is changed by simply multiplying by a frailty variable. The authors show how to modify the hazard rate to take into account competing risks, and caution the reader in remembering the difference between the cumulative incidence function and the cumulative cause-specific hazard. To experts in probability theory and the theory of stochastic processes such a description may seem trivial or imprecise, but for those who really want to understand the subject, and do so outside the constraints of formal reasoning, the authors’ “intuitive discussion” is very helpful and considerably shortens the time to learn the important ideas. Of fundamental importance in applying survival analysis are the nonparametric estimators of the cumulative hazard rate going by the names of the Nelson-Aelen and Kaplan-Meier estimators."
"The nonparametric approach in survival analysis is well documented and the use of Nelson-Aalen estimator for estimating cumulative hazard function, the Kaplan-Meier estimator of the survival function, the nonparametric tests for one- and k-sample, and finally the popular Aalen-Johansen estimator for transition probability matrix of a nonhomogeneous Markov process have been well written in Chapter 3. For the latter model, the reader may also refer the brilliant work of Martinussen and Schieke (2006), while the former model is almost prevalent in any book on survival analysis. While these two models are discussed in Chapter 4, the parametric regression models are considered in chapter 5, and IIRC Prof. Borgan had developed the parametric regression models under the counting process approach in one of his 1980's papers."
"In this book he and his coauthors take the counting process point of view to develop the theory of multivariate survival analysis and fraility models."
"Clear and great examples."
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Spillover: Animal Infections and the Next Human Pandemic
Ebola, SARS, Hendra, AIDS, and countless other deadly viruses all have one thing in common: the bugs that transmit these diseases all originate in wild animals and pass to humans by a process called spillover. *Starred Review* Exemplary science writer Quammen schools us in the fascinating if alarming facts about zoonotic diseases, animal infections that sicken humans, such as rabies, Ebola, influenza, and West Nile. Drawing on the truly dramatic history of virology, he profiles brave and stubborn viral sleuths and recounts his own hair-raising field adventures, including helping capture large fruit bats in Bangladesh. Along the way, Quammen explains how devilishly difficult it is to trace the origins of a zoonosis and explicates the hidden process by which pathogens spill over from their respective reservoir hosts (water fowl, mosquitoes, pigs, bats, monkeys) and infect humans. He also adds a powerful measure of moral witness: ecological destruction is greatly to blame for our current peril.”. - Dwight Garner, The New York Times “David Quammen [is] one of that rare breed of science journalists who blend exploration with a talent for synthesis and storytelling.”. - Nathan Wolfe, Nature. That bodes well for his new book, whose subject really is thriller-worthy: how deadly diseases (AIDS, SARS, Ebola) make the leap from animals to humans, and how, where, and when the next pandemic might emerge.”. - Kathryn Schulz, New York Magazine.
Reviews
"I read this for a biology class and it was a good read."
"The book seeks not only to enlighten us to thrilling tales of discovery but also urges us to examine our role in these emerging viruses."
"It was just lacking in more non-human animals (lots of apes and bats, a little of a few others) and Quammen's interesting and humorous travelogues."
"David Quammen draws on his many travels, interviews, and research to paint vivid stories about the history of a handful of zoonotic diseases and the science used to study them."
"But recently there have been programs that have basically cleared an area of deer (much easier to do that than with mice) and new case of Lyme dropped by over 90%."
"The author explains extremely difficult subjects and concepts such that a lay person can readily understand them and covers diverse items from the origin of the AIDS virus in Cameroon (the who, the where and the how - as he puts it), to an outbreak of tent caterpillars in Montana."
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Best Parasitology

This Is Your Brain on Parasites: How Tiny Creatures Manipulate Our Behavior and Shape Society
“Engrossing … [An] expedition through the hidden and sometimes horrifying microbial domain.” — Wall Street Journal “Fascinating—and full of the kind of factoids you can't wait to share.” — Scientific American Parasites can live only inside another animal and, as Kathleen McAuliffe reveals, these tiny organisms have many evolutionary motives for manipulating the behavior of their hosts. The horror and revulsion we are programmed to feel when we come in contact with people who appear diseased or dirty helped pave the way for civilization, but may also be the basis for major divisions in societies that persist to this day. "- BookForum “A fascinating account of an extraordinary suite of biological phenomena, only recently come to light and proving that given enough time and enough evolving species to work with, natural selection can accomplish almost anything.”. - Edward O. Wilson , Professor Emeritus, Harvard University, author of Consilience . In company with the best science writers, she shows us that reality can be way more interesting than fiction.”. - Valerie Curtis , Director of the Environmental Health Group of the London School of Hygiene & Tropical Medicine and author of Don’t Look, Don’t Touch, Don’t Eat “Be prepared to throw away all your preconceptions about the order of life.
Reviews
"McAuliffe’s article on toxoplasmosis in the 2012 Atlantic “How Your Cat is Making You Crazy” is probably the reason for the word parasites in the title, but the subtitle, “How Tiny Creatures Manipulate Our Behavior and Shape Society,” is a more accurate portrayal of the topic of this excellent book. Here’s an overview of the chapters: 1 – The beginning of the study of parasites and microbs effecting the behavior of animals and humans. 5 – Rabies; toxocara (roundworms), and other parasites that effect “our essential sense of self – our moods, appetites, behaviors, and reasoning abilities.”. 6 – Gut microbiota. 8 – Behavioral immunity – things animals and humans instinctively do to heal our wounds and protect us from parasites. This book offers a lot to think about with far reaching impacts on our personal health and the state of the world."
"How about Hillary Clinton's extended bathroom break during a Democratic primary debate? Do you wonder about whether you have the larger anterior insula relative to total brain size? Remember the following tips: (1) eat vegetables that have been scrubbed throughly; (2) wear gloves while gardening; (3) cook meat well or, if you prefer it rare, freeze it first to kill the microbe's cysts ㅡT.gondii produces thick-walled cysts in the animal's muscle. Ectoparasites and microscopic parasites may exist anywhere around you... and jeopardize you, your partner, and your offsprings.... I bet you will totally lose track of the time while reading."
"McAuliffe surveys current cutting-edge research linking the impact of various parasites not only on the physical health and well-being of their hosts, but also on psychological functioning as well as social and cultural developments. Some of the studies she cites include ones with which I was already familiar – like the jewel wasp which turns a cockroach into a zombie as a living food source for her larva, or the molecule that can change a rat’s protective aversion to the smell of cat urine into attraction."
"Great insight into who might really be behind the wheel."
"Still reading this - as a non-scientist, I read it in small bites, then digest (ha!)."
"The world is stranger than we can ever imagine."
"Not a bad thing but seems to drag out the content form the core facts at hand."
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Best Tropical Medicine

Field Guide to Wilderness Medicine E-Book
Field Guide to Wilderness Medicine - based on Dr. Auerbach’s critically acclaimed text Wilderness Medicine - offers fast-access solutions to all of the medical situations that can occur in non-traditional settings . Get the wilderness medicine skills you need now with new chapters on foot problems and care, global humanitarian relief and disaster medicine, Leave No Trace principles, and high-altitude medicine, as well as lists to prepare a variety of survival kits for different settings and patient populations. This book is actually portable, small enough to keep in a first aid kit or to take on a trip, but packed with concise and useful information on nearly every subject and scenario imaginable. "-Ericl Ellingson, MD(Regions Hospital and Level 1 Trauma Center) Doody Review: 4 stars Dr. Paul S. Auerbach, FACEP, FAWM, is the Redlich Family Professor of Surgery in the Division of Emergency Medicine at Stanford University School of Medicine.
Reviews
"Very fast shipping- I had an earlier edition but this newest one was great- an excellent resource!"
"fab."
"Cool book to have on any camping hiking or just to have by the toilet."
"Great reviews and discussions for wilderness treatment."
"Amazing amount of information."
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Best Communicable Diseases

The Hot Zone: The Terrifying True Story of the Origins of the Ebola Virus
The Hot Zone tells this dramatic story, giving a hair-raising account of the appearance of rare and lethal viruses and their "crashes" into the human race. And in 1989 Philippine monkeys in a Reston, Va., research lab, found to be infected with Ebola, were the target of a U.S. Army-led biohazard task force that decontaminated the lab, exterminating hundreds of monkeys to prevent the possible airborne spread of the disease to humans. In a horrifying and riveting report, portions of which appeared in the New Yorker , Preston ( American Steel ) exposes a real-life nightmare potentially as lethal as the fictive runaway germs in Michael Crichton's The Andromeda Strain.
Reviews
"I'm writing this review now because, 1- the current (July 2014) outbreak of Ebola is "the deadliest in recorded history," and 2- I've NEVER forgotten the book. The thing that is so terrifying is the way the poor people who contract the disease die."
"I learned a lot about the virus. After reading this book, im able to read between the headlines of what is being said and more importantly, what's NOT being said. Medical researchers working with the virus give share their information."
"I bought this book in its hard-cover version when it first came out, quite a few years ago, and what with the recent Ebola crisis in Africa and now in the news here in the U.S., I wanted to re-read it. I am dismayed that the CDC is still "learning" how to contain this disease, when the knowledge has been in use by the U.S. Army, and various charitable organizations in Africa for many years."
"A scary, eye opening book about Ebola. He describes in detail the Ebola Reston outbreak in Maryland."
"A must read for anyone who wants the scientific truth about this disease, how it can be spread & how easily & quickly it can mutate."
"Although twenty years old, the information is timely and so. pertinent for our age when Ebola is devastating Africa and may be advancing thought the world."
"Because you will be terrified every time you have a tiny headache. Because you will want strangers to stay far away from you, especially if they are breathing. Because you will realise that your government, our government, the government will probably be unable to stop a proper Ebola virus. Because you will forgive the sometimes over detailed writing because you are completely absorbed in the horror. Because this is not fiction, this is real, this is here, this is now. And this is a gripping, interesting, well put together, well researched non-fiction book that reads like an adventure, a horror and a thriller all at once. Viruses are clever little buggers and best we be afraid."
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