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Best Medical Biotechnology

Preserving the Promise: Improving the Culture of Biotech Investment
Explains why translation of biotech discovery into medicine succeeds so infrequently that it’s been dubbed the Valley of Death Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better. He is currently an associate professor at Lankenau Institute for Medical Research (LIMR) in Pennsylvania and an attending physician at the Lankenau Medical Center, where he specializes in medical oncology, runs an immunology research laboratory, and teaches in the Hematology/Oncology fellowship program. He co-created and serves as program executive for the Commercialization Acceleration Program (CAP) at the Wharton School of the University of Pennsylvania, a consultancy focused on the development and funding of technology-based start-up companies. Fishman holds undergraduate and graduate degrees from the University of Pennsylvania and The University of Texas, teaches in the MBA program at Philadelphia University, and is an in-demand speaker at biotechnology development events around the United States, including recent engagements at Yale’s Healthcare Colloquium, Harvard’s i-lab, and the National Science Foundation.
Reviews
"Ordered for faculty at the University of Pennsylvania, no complaints."
"It is the only book that clearly explains the pitfalls that are unique to biotech investment: high technical complexity, high risk, a long timeline to return on investment (ROI), the extreme technical complexity and how to overcome them. It then explains how each of these Gaps works against biotech investors and gives examples of how some biotech innovators are making changes for the better."
"Dessain and Fishman have written a much needed and honest account of the challenges early stage biotechnology companies face when seeking funding. Preserving the Promise is written by two experienced professionals - one is a doctor, professor, and biotech company founder, and the other is a successful businessman who is an early stage angel investor. Funding for early companies is extremely small, compared to potential for success, especially for the ground-breaking science the is required to create high potential drugs for large populations."
"Dessain’s and Fisherman’s “Preserving the Promise – Improving the Culture of Biotech Investment” is easy to read and understand and ideally suited for anyone considering to participate in this game as well as those that are involved already. Compared to other industries there often are no well-defined objective criteria to judge a proposed product and this is further blurred by unknowns and high attrition rates lurking in the clinical development program. Preserving the Promise also looks at the roles of the Public Sector (Technology Transfer Offices) and Scientists (Inventors) and provide helpful insight into the different mechanisms, forces and sometimes lunacies at play."
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The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care
And yet many of these digital medical innovations lie unused because of the medical community’s profound resistance to change. In The Creative Destruction of Medicine , Eric Topol—one of the nation’s top physicians and a leading voice on the digital revolution in medicine—argues that radical innovation and a true democratization of medical care are within reach, but only if we consumers demand it. Arnold S. Relman, New York Review of Books “As an introduction for the lay reader to the sophisticated digital technology now being applied to medical care, and as an explanation of the rapidly advancing science of medical genetics and the new revelations from the sequencing of the human genome, Topol’s book is a tour de force.” Siddhartha Mukherjee, author of The Emperor of All Maladies: A Biography of Cancer. I recommend him highly.” A. J. Jacobs, author of My Life as an Experiment and The Year of Living Biblically “It may sound like hyperbole, but it’s true: Medicine is undergoing its biggest revolution since the invention of the germ theory. His book should be prescribed for doctors and patients alike.” Steve Case, co-founder, AOL, and founder of Revolution LLC “Health care is poised to be revolutionized by two forces—technology and consumerism—and Dr. Eric Topol explains why. Fasten your seat belts and get ready for the ride—and learn what steps you can take to begin to take control of your health.” James Fowler, Professor of Medical Genetics and Political Science, UC San Diego, and author of Connected “Eric Topol is uniquely positioned to write such a timely and important book. From this vantage point, he can see unifying themes that will underlie the coming revolution in population and personal health, and he communicates his vision with vibrant energy. Smart patients will push the many stakeholders in health to accelerate change as medicine adapts to a new world of information and technology.” Jeffrey Immelt, Chairman and CEO of General Electric “Eric Topol has been a longtime innovator in healthcare. Dr. Topol explains how iPhones, cloud computing, gene sequencing, wireless sensors, modernized clinical trials, internet connectivity, advanced diagnostics, targeted therapies and other science will enable the individualization of medicine—and force overdue radical change in how medicine is delivered, regulated, and reimbursed. This book should be read by patients, doctors, scientists, entrepreneurs, insurers, regulators, digital engineers—anyone who wants better health, lower costs, and participation in this revolution.” Misha Angrist, Assistant Professor, Duke Institute for Genome Sciences & Policy, and author of Here is a Human Being “Eric Topol is that rare physician willing to challenge the orthodoxies of his guild. It is a necessary heresy.” George Church, Professor of Genetics, Harvard Medical School “What happens when the super-convergence of smart phones further combines with million-fold lower-cost genomics and diverse wearable sensors? In the context of increasingly unaffordable health care costs, suboptimal quality of care delivery, a tsunami of preventable chronic illness, and new accountabilities for consumer’s health choices and behaviors, this book helps all of us to think about solutions in new and exciting ways!” Juan Enriquez, Managing Director, Excel Venture Management, and author As the Future Catches You “Much of the wealth created over the last decades arose out of a brutal transition from ABC’s to digital code. This book is a road map of what is about to happen.” Elias Zerhouni, M.D., President, Global R&D, Sanofi and former director, National Institutes of Health “If we keep practicing medicine as we know it today, healthcare will become an unbearable burden. In a comprehensive and well researched tour de force, Eric Topol, always a clear and uncompromising thought leader of his generation, challenges us to imagine the revolutionary potential of a world where medical information no longer belongs to a few and can be automatically collected from the many to greatly improve healthcare for all. Along the way, Dr. Topol provides a fascinating compendium of stories about the shortcomings of medicine as it is currently practiced and how the revolutionary discoveries coming since the first sequencing of the human genome a decade ago will shape the delivery of healthcare in the 21st century.”. “In an upbeat, comprehensive volume, Dr. Topol has woven the prevailing technological undercurrents of the post-PC world—its power of many; its Gucci of gadgets; its cloud ecosystem; its ‘Arab Spring’ of apps; and its ubiquitous, calm computing—with the disruptive innovations of biomedicine, to create a compelling account of how this bio-digital transformation will hasten personalization of the highest quality of medical care.”. [T]he book provides an excellent summary of the current state of medical genetics and how fast it is progressing, with examples that may surprise even those working in medicine.”. Nature Genetics “Deriving inspiration from the economist Joseph Schumpeter, Topol proposes nothing less than the ‘creative destruction’ of medicine as it is currently practiced, replacing it with a brave new world in which interconnected technologies dramatically improve patient outcomes…. It can only be hoped, as the convergence he so convincingly predicts materializes, that the barriers erected by the gatekeepers of yesterday’s paradigms will be easily dismantled so as not to impede the benefits it promises.”. It’s highly recommended, because Topol has a unique vantage point: he’s one of the few researchers to have played an important role in the old, mass-market medicine world and the newer, genetically focused one.”. From cell phones that automatically collect medical data, to biosensors, advanced imaging, individualized prescriptions and gene-specific drugs, Topol’s book leads readers through science-fiction-sounding scenarios that may soon be a reality.”. [Topol] does a good job of explaining subtleties to a lay audience—such as why some genetic testing for predicting disease is valid and useful, and why much is not.” Wall Street Journal “ The Creative Destruction of Medicine …offers an illuminating perspective on the coming digitization of health care.”. Trained at Johns Hopkins University, he conducted one of the first trials of a genetically engineered protein for treating heart attacks, and was the founder of the world’s first cardiovascular gene bank at the Cleveland Clinic.
Reviews
"I am an electrical engineer who worked in high tech (and the figures feel as if they came from a strategy/marketing presentation in that field)."
"It just sucks that the average person interested in health isn't going to be able to read this book, nor are ideas like this the impetus for social change, because unfortunately complicated ideas from smart people aren't understood by most and thus don't go anywhere without social media efforts and popularity."
"The medical system in place from (say) the mid-20th century forward, will not be able to handle the continual flow of retiring baby boomers, let alone senior citizens with ever increasing life expectancies. It would seem the dentists got to the answer faster than medical doctors were able to: Delegate anything and everything you can to less expensive staff so you can see more patients and reap the rewards of an expanded practice."
"The title attributes this to the digital revolution, but the book is at least as much about the impact of the science of genetics. The combination of these two will produce a medical approach far more closely targetted to the individual, far more precise, and -- ulimately -- far cheaper. The one instance in which that may be true is the section on the role of genomics in medicine, but that is a hard thing to explain, and not part of the general medical knowledge base -- Dr. Topol notes that at the last report, only 2 out of 150 U.S. medical schools had "more than a brief, cursory curriculum" devoted to genomics beyond simple Mendelian traits. Stylistic issues, however, should not deter readers: there's so much very important stuff in this book that it's worth a bit of a slog."
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FDA Establishment Inspections: Pharmaceutical, Biotechnology, Medical Device and Food Manufacturing Concise Reference
Establishment Inspections, Chapter 5 of the FDA's Investigations Operations Manual, details every step FDA inspectors are required to follow when conducting a facility inspection. She has provided guidance in regulatory compliance, corporate structuring, restructuring and turnarounds, new drug submissions, research and development, product commercialization strategies, operational, project and contract management, and new business development.
Reviews
"This reference tool provides you everything you need to know about what the FDA does during their inspections."
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Best Medical Nutrition

The China Study: Revised and Expanded Edition: The Most Comprehensive Study of Nutrition Ever Conducted and the Startling Implications for Diet, Weight Loss, and Long-Term Health
In 2005, Colin and his son Tom, now a physician, shared those findings with the world in The China Study , hailed as one of the most important books about diet and health ever written. Featuring brand new content, this heavily expanded edition of Colin and Tom’s groundbreaking book includes the latest undeniable evidence of the power of a plant-based diet, plus updated information about the changing medical system and how patients stand to benefit from a surging interest in plant-based nutrition. He is the founder of the T. Colin Campbell Center for Nutrition Studies and the online internationally recognized plant-based nutrition certificate offered by the T. Colin Campbell Center for Nutrition Studies in partnership with eCornell.
Reviews
"I dumped the western diet and my 50yr habit of what I ate since birth to simply eating...plants. Im going on to my 3rd yr now after reading this book and changing to whole plants I feel like I did when I was in grade school with energy and skip in my step. Never being a gym person, I've recently begun to add modest exercise 1 or 2x per week in the past 6 months which makes me feel additionally very good after a 45 min workout. My version of it goes like this: 1-1.5 cups of raw oatmeal, sliced fresh strawberries, blueberries, figs, dates, rasins, prunes, add fresh blackberries and/or raspberries or whatever fruit you want. The other thing I do is make 2-liters of green smoothies and drink it all throughout my day. I change up the frozen fruit in the smoothie (I'll use frozen mangos, pineapple, strawberries...for leafy green I may use a combo of baby spinach, kale, chard); here is an example of a smoothie I made today: 3 cups baby spinach, 1.5 cups of frozen berries (strawberries, blueberries, raspberries, blackberries), 2 apples, 2 pears, ground flax seed and chia seeds, 2 bananas, 2fl-oz of almond milk+2fl-oz of spring water. After making the smoothie, take two to three large containers of the smoothie with u to work and drink this all through the day. For dinner, I started out using the "big salad" recipe that can be found at chrisbeatcancer.com In two weeks of consisitent eating whole plant based diet, I began to notice the change and feel better overall; the positive change in two weeks kept me going, week after week, month after month."
"Americans, Australians and New Zealanders drink the most milk, and have the most bone fractures from middle age on. The facts, usually contrary to everything we’ve been taught, keep coming fast and hard. They have corrupted our universities with grants, infiltrated government agencies to keep the truth at bay, and spend billions advertising their false promises. The scientific proof is endless – and so are the defenders of the SAD – Standard American Diet - that is about one third animal, between meat and dairy. When I read the first China Study ten years ago, I immediately went back online and ordered a whole case of them."
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Best Medical Prosthesis

Artificial Parts, Practical Lives: Modern Histories of Prosthetics
From the wooden teeth of George Washington to the Bly prosthesis, popular in the 1860s and boasting easy uniform motions of the limb, to today's lifelike approximations, prosthetic devices reveal the extent to which the evolution and design of technologies of the body are intertwined with both the practical and subjective needs of human beings. "These essays are valuable first forays into the history of prosthetics."
Reviews
"This book covers a lot of really interesting perspectives on prosthetics and the world in which we live; from the history of prosthetics to the cultural influences of prosthetics and the science behind the technology."
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Best Medical Transportation

ASTNA Patient Transport - E-Book: Principles and Practice (Air & Surface Patient Transport: Principles and Practice)
Comprehensive overviews familiarize you with the most common diseases and injuries encountered in practice, accompanied by important management considerations to help you ensure the most effective communication and the safest patient care in all transport settings. 3 new chapters highlight emerging trends in transport care: The Use of Technology During Transport, including ventricular assist devices, a chapter devoted to Mechanical Ventilation, and Military Transport with EnRoute care. Obesity considerations included in the Patient Assessment and Preparation for Transport chapter outline special challenges and possible solutions for the care of obese patients.
Reviews
"This should be in every paramedic and transport nurse's library."
"I purchased this book as a guide to critical care nursing and to help with the CFRN exam."
"This book is exactly what I was looking for to review for my job interview that included a written test."
"This book has been an invaluable resource for studying for CFRN."
"Although the information is detailed and important it does not include practice questions and answers with rationales."
"This book is really helpful."
"The book has stains of food in it but other than that it's good ."
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Best Lasers in Medicine

Stop Endometriosis and Pelvic Pain
Stop Endometriosis and Pelvic Pain provides extensive information about the realities and the myths of endometriosis and pelvic pain and various treatment options. This book is a most welcome source of hope for women to break open the taboos about discussing endometriosis and get the medical community to recognize their obligation to rethink how this disease is treated.” —Susan Sarandon, actress. Andrew Cook is just such a physician and surgeon whose book provides expert and comprehensive advice that will benefit many patients.”— G. David Adamson MD, FRCSC, FACOG, FACS, Director of Fertility Physicians of Northern California, Adjunct Clinical Professor at Stanford University, Clinical Associate Professor at the University of California San Francisco. There are sections of it that totally resonate with the experience of endometriosis.” — Mary Lou Ballweg, president and executive director of the Endometriosis Association, Milwaukee, Wisconsin. “In Stop Endometriosis and Pelvic Pain, Dr. Andrew Cook shows exactly why so many women are improperly treated and left to suffer and why his rate of success is so high.
Reviews
"On the other hand, because my appointments seem to take a long time to go over all of my issues, I would often refrain from asking questions out of respect for his time. I absolutely dread the idea of her having to go through any of this. My greatest hope is that Dr. Cook's idea of Endometriosis being its own specialized field (e.g. Cardology) comes to fruition. This would mean my daughter would have several physicians to choose from, instead of trying to find a needle in a haystack of Endo-illiterate physicians."
"This book is a relief and consolation that 1. there is someone out there who actually understands the misery this condition brings and 2. something can be done ( you don't have to live with this the rest of your life)."
"I strongly recommend this book to any woman who is suffering with pelvic pain and feeling lost."
"This book gives you good explanations as to the cause, treatment options, patient advocacy, and hope in the face of a disease that can be a life long battle."
"This is an essential read for anyone who thinks they may have or have been diagnosed with endometriosis or adenomyosis."
"Both books describe what it takes to find endometriosis, and how to best treat it, along with adhesions."
"By April of this year I was able to travel 400 miles to get to one great endometriosis excision specialist."
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